United may have a positive boost with the potential return of wing-back Noussair Mazraoui, who could participate in the game if he hasn't experienced any further setbacks from an unspecified injury that has limited him to just three appearances this season.
His return would give Amorim more flexibility with his lineup, which is in need of rotation despite not having European football this season.
However, one player who won't be returning to the pitch this weekend is Lisandro Martinez, who underwent surgery on a torn anterior cruciate ligament suffered in February against Crystal Palace.
Although Martinez is expected to return this month, he is more likely to be back in November, as Amorim wants to ensure he doesn't rush his recovery and risk exacerbating the injury.